Signaling
Arizona GOP censures Cindy McCain, Jeff Flake and Doug Ducey, signaling a fractured party in a key swing state
The decision to censure those three Republicans — in addition to re-electing controversial chairwoman Kelli Ward — solidified the rightward shift of the official party, while also reflecting the deep fractures among Arizona Republicans over the future of the GOP, which suffered bruising defeats at the ballot box in 2020 in this increasingly purple state. …
Pancreatic Cancer Cells Avoid Starvation by Signaling to Nerves
Pancreatic cancer cells avert starvation by signaling to nerves, which grow into dense tumors and secrete nutrients. This is the finding of a study with experiments in cancer cells, mice, and human tissue samples published online November 2 in Cell. The study addresses pancreatic ductal adenocarcinoma (PDAC), the deadliest cancer of the pancreas with a …
Disruption of Immune Signaling In Utero Could Impact Susceptibility to Rotavirus
Researchers at the University of Toronto have discovered how a brief disruption to a molecular pathway in the guts of mice before they are born can compromise adult immunity to a common and often deadly intestinal virus. The researchers found that in utero inhibition of molecular signaling in the ‘lymphotoxin pathway,’ long known as …
