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PC14586 selectively stabilizes the p53 Y220C mutant and restores p53 activity Robust in vivo tumor regression observed with once daily oral dosing Pharmacodynamic biomarkers of p53 activation developed for clinical trials PC14586 is being tested in a Phase 1/2 clinical trial in patients with advanced solid tumors that have a p53 Y220C mutation CRANBURY, N.J., …

Share Tweet Share Share Email Customer identity and access management software (CIAM) provider, LoginRadius, was recently ranked #1 among 13 global competitors by Forrester Wave™ Management Q4 2020 report. The leading provider of CIAM continues innovating, placing it ahead of significant competitors once again. LoginRadius Continues to Lead …

NASHVILLE, Tenn. (WTVF) — More people are getting access to the COVID-19 vaccine than ever before, expanding to everyone 16 and up in less than two weeks. But now, the technology driving the Pfizer and Moderna vaccines could end up helping cure other diseases. With the increased rollout of the first two COVID vaccines, more …

Hampton had 4th quarter leads in their first two games and lost. This time the won 18-13. NEWPORT NEWS, Va. — Not this time said the Hampton Crabbers. This time Hampton hung on to a fourth quarter lead to beat Warwick 18-13. The Crabbers had fourth quarter leads in the prior two games against Phoebus …

Stocks closed lower Wednesday as another rise in bond yields fueled concerns on Wall Street that higher inflation is on the way as the economy picks up. The Standard & Poor’s 500 index dropped 1.3%, shedding an early gain. The pullback is the benchmark index’s second straight loss after it clocked its best day in …

A man wearing a protective mask walks past an electronic stock board showing Japan’s Nikkei 225 index at a securities firm Wednesday, March 3, 2021, in Tokyo. Stocks advanced in Asia on Wednesday after a wobbly day on Wall Street, when the S&P 500 gave back …

METTAWA, Ill., March 01, 2021 (GLOBE NEWSWIRE) — Brunswick Corporation (NYSE: BC) continues to build on its ACES (Autonomy, Connectivity, Electrification & Shared Access) strategy to develop solutions to further improve boater experiences by advancing the efficiency and capabilities of its core product lines. In support of this effort, the Company has announced that Jason …

DevOps and agile methodologies certainly have shifted the priorities and practices of technology teams. Now, as organizations prepare for the post-Covid boom in activity ahead, these efforts will need to be at the forefront of cultural change and engaging customers. DevOps and agile need to break out of the IT department and become everyone’s best …

The 2021 Daytona 500 is the 63rd running of the Great American Race at the Daytona International Speedway in Daytona Beach, Fla. The race will be broadcast on Fox and is streaming on fuboTV, with a seven-day free trial available. This year the race will look different than usual due to the coronavirus pandemic. Rather than …

His confirmation will fill a critical role in the new administration and he’ll be expected to swiftly begin rolling back Trump administration immigration policies while juggling the response to a global pandemic and national security threats, along with restoring a department that’s been rattled by leadership turnover and vacancies in recent years. The Senate also …