Victoria will enter stage four restrictions from 11.59pm tonight until 11.59pm on Wednesday.
Victorians will only be able to leave their homes for one of the four essential reasons, including shopping for necessary goods and services, essential work or education if it cannot be done from home, exercise for two hours per day with household members, an intimate partner or one other person only.
The five-kilometre travel radius has also be reinstated and masks must be worn everywhere in public.
Schools will also close, but will remain open for vulnerable children or the children of permitted workers.
Places of worship will also close and religious gatherings and ceremonies will not be permitted.
Weddings are not permitted unless on compassionate grounds.
Mr Andrews said the state needed a “circuit-breaker” to control the rise in coronavirus cases.