Emergency crews have rushed to the scene after six-vehicles crashed on the M60.
The smash happened at about 7.30am between junction 20 for Blackley and junction 21 for Hollinwood.
It is currently causing delays of around an hour for motorists.
The M6 northbound near Warrington has also been closed after a lorry jack-knifed following a crash.
The lorry crashed with a car at around 8.30am.
North West Motorway Police tweeted: “There is a FULL closure in place.
“If you haven’t yet set off please find an alternative route. Those in the traffic, please wait for police instructions.”
There are currently tailbacks stretching to junction 20, according to traffic website Inrix.